Search results for "Artificial cornea"

showing 3 items of 3 documents

Long-Term in vivo Evaluation of Orthotypical and Heterotypical Bioengineered Human Corneas.

2020

Purpose: Human cornea substitutes generated by tissue engineering currently require limbal stem cells for the generation of orthotypical epithelial cell cultures. We recently reported that bioengineered corneas can be fabricated in vitro from a heterotypical source obtained from Wharton’s jelly in the human umbilical cord (HWJSC). Methods: Here, we generated a partial thickness cornea model based on plastic compression nanostructured fibrin-agarose biomaterials with cornea epithelial cells on top, as an orthotypical model (HOC), or with HWJSC, as a heterotypical model (HHC), and determined their potential in vivo usefulness by implantation in an animal model. Results: No major side effects …

0301 basic medicinePathology02 engineering and technology:Chemicals and Drugs::Carbohydrates::Polysaccharides::Sepharose [Medical Subject Headings]Umbilical cord:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]heterotypical human corneaTissue engineering:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Lagomorpha::Rabbits [Medical Subject Headings]Cornea:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Optical Imaging::Tomography Optical::Tomography Optical Coherence [Medical Subject Headings]:Organisms::Eukaryota::Animals [Medical Subject Headings]:Technology and Food and Beverages::Technology Industry and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Biocompatible Materials [Medical Subject Headings]Slit lamp021001 nanoscience & nanotechnologymedicine.anatomical_structure:Anatomy::Sense Organs::Eye::Anterior Eye Segment::Cornea [Medical Subject Headings]tissue engineeringStem cell0210 nano-technologyBiotechnology:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Fibrin [Medical Subject Headings]medicine.medical_specialtyHistologyStromal celllcsh:BiotechnologyBiomedical EngineeringCélulas madre mesenquimatosasBioengineering:Anatomy::Embryonic Structures::Fetus::Umbilical Cord [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Animal [Medical Subject Headings]03 medical and health sciencesIn vivolcsh:TP248.13-248.65medicine:Anatomy::Cells::Connective Tissue Cells::Stromal Cells::Mesenchymal Stromal Cells [Medical Subject Headings]:Technology and Food and Beverages::Technology Industry and Agriculture::Engineering::Bioengineering::Cell Engineering::Tissue Engineering [Medical Subject Headings]Wharton’s jelly stem cellsbioengineered corneabusiness.industryTissue engineringeye diseasesEpitheliumCórnea:Anatomy::Cells::Epithelial Cells [Medical Subject Headings]:Anatomy::Tissues::Connective Tissue::Wharton Jelly [Medical Subject Headings]030104 developmental biologyIngeniería de tejidossense organsbusinessartificial cornea
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Image quality with multifocal intraocular lenses and the effect of pupil size

2007

Purpose To analyze the image quality with a refractive and 2 hybrid refractive–diffractive multifocal intraocular lenses (IOLs) in vitro to determine the IOL modulation transfer function (MTF) following the EN-ISO international standard for distance and near vision and to study the IOLs' behavior with different pupil sizes. Setting Fundacion Oftalmologica del Mediterraneo, Valencia, Spain. Methods This study evaluated 4 IOLs: the hybrid refractive–diffractive AcrySof ReSTOR SN60D3 (Alcon) and Tecnis ZM900 (AMO), the refractive ReZoom NXG (AMO), and the monofocal AcrySof SN60WF (Alcon). The MTF was calculated from the cross-line spread function recorded with the OPAL Vector System (Image Sci…

Artificial corneaOptics and PhotonicsImage qualitymedicine.medical_treatmentIntraocular lensProsthesis DesignModels BiologicalPupilContrast SensitivityOpticsOptical transfer functionmedicineHumansImaging scienceMathematicsLenses IntraocularFourier Analysisbusiness.industryPupil sizePupilMultifocal intraocular lensSensory SystemsOphthalmologyOptometrySurgerybusinessJournal of Cataract and Refractive Surgery
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Imaging Quality of Bifocal Piggyback Intraocular Lens versus ReSTOR and TECNIS Multifocal Lenses

2009

Purpose The imaging quality provided by a piggyback integrated by a monofocal intraocular lens (IOL) + a bifocal IOL of zero power and +3.75 diopters of addition is compared with the optics quality of a simple multifocal IOL of the same power and addition. Methods The imaging quality was evaluated by determining the modulation transfer function (MTF), using an artificial eye simulating in vivo conditions of the anterior chamber, including an artificial cornea and a wet cell containing physiologic solution where the IOL was positioned. The MTFs of the bifocal piggyback for near and distance vision were measured, with pupil diameters of 3 and 5 mm, and compared with the MTFs of an equivalent …

Artificial corneaOptics and Photonicsmedicine.medical_specialtybusiness.product_categoryMaterials sciencemedicine.medical_treatmentVisual AcuityIntraocular lensEyeRefraction OcularPupil03 medical and health sciences0302 clinical medicineOptical transfer functionOphthalmologymedicineHumansMultifocal lensesDioptreLenses IntraocularDepth PerceptionStrehl ratioGeneral MedicineModels TheoreticalOphthalmologyImaging quality030221 ophthalmology & optometryArtificial Organsbusiness030217 neurology & neurosurgeryEuropean Journal of Ophthalmology
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